The most compelling evidence for the latter statement is the neurodegenerative pathology termed Vanishing White Matter Disease (VWMD) or eIF2B-leukodystrophy, caused by two mutated alleles of any of the 5 genes encoding eIF2B subunits (OMIM 306896) [3]. The gene discussed is EIF2B5; the disease is leukoencephalopathy with vanishing white matter.