CD44 and melanoma: Collagen type IV was shown to promote adhesion, migration, and spreading of melanoma cells [61] via interaction with chondroitin sulfate proteoglycan via CD44 or β1 integrin [62,63] involving the signaling cascades related to p(Tyr127)FAK and paxillin [64], PI3-kinase, and protein kinase C (PKC) [65].