Further, TLA1 modulates Foxp3 expression in Tregs and its function, and murine model of colitis has seen the alleviation of colitis when treated with Tregs expressing low levels of TLA1.TLA1 may promote the maintenance of Treg suppressor function in a death domain receptor 3 (DR3) dependent manner [41]. This evidence concerns the gene TNFRSF25 and colitis.