Besides its ability to control the transactivation of genes involved in BA biosynthesis and transport along the enterohepatic tract, and to contribute to liver regeneration and growth, FXR has been proved to counterbalance nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)—mediated transcription of proinflammatory cytokines, having a role in hepatic repair in liver fibrosis [61,62,63]. The gene discussed is NR1H4; the disease is Hepatic fibrosis.