Thus, in intrahepatic cholestasis of pregnancy (ICP), a disease that occurs in 1/200 pregnancies in Caucasian women and can result in intrauterine fetal death, four heterozygous variants of FXR were found in or near the transcribed sequence of FXR being associated with downregulation of FXR target genes encoding for SHP and organic anion transporting polypeptide 1B3, upon BA stimulation [13,14]. This evidence concerns the gene NR1H4 and Intrahepatic cholestasis of pregnancy.