NR1H4 and liver cancer: FXR gene deletion in mice demonstrated that FXR nuclear receptor plays a role in regulating hepatic inflammation, since FXR−/− mice had high levels of proinflammatory cytokines such as interleukin 1 beta (IL-1β) and were prone to developing liver cancer due to abnormal expression of β-catenin and c-Myc oncogenes [76,77,78].