Another interesting study was performed on PX20606 (PX), a nonsteroidal agonist of FXR, in regard to its effect on portal hypertension besides liver fibrosis in experimental models of non-cirrhotic (partial portal vein ligation or PPVL) and cirrhotic (carbon tetrachloride, CCl4) models [100]. Here, NR1H4 is linked to portal hypertension.