The presence of about 40% of germline mutations of CDKN2A causes FAMMM (Familial atypical multiple mole melanoma), an autosomal, dominantly inherited disorder characterized by multiple nevi and atypical nevi, and an increased risk for malignant melanoma [49]; patients with FAMMM syndrome have an increased risk of about 50% of developing pancreatic cancer [50]. This evidence concerns the gene CDKN2A and pancreatic neoplasm.