Ki-67 is a nuclear and nucleolar protein expressed in proliferating cells but not resting cells, and high expression levels have been demonstrated to be associated with extra-aerodigestive tract primary site, B symptoms (any of the following: unexplained fever >38 °C, drenching night sweats, or loss of >10% body weight within 6 months), and tumor bulk [49], conferring worse survival outcomes [49,50]. This evidence concerns the gene MKI67 and neoplasm.