Previous studies have reported that the expression of MIR4435-2HG, PCED1B-AS1, AL512274.1, AL354836.1, MIR9-3HG were associated with tumorigenesis and regulated cell death in various tumor types, which support the further identification and exploration in HNSC [68,69,70,71,72]. The gene discussed is PCED1B; the disease is neoplasm.