Several lncRNAs have been functionally characterized in previous research on pain or depression, such as XIST, uc.48+, NEAT1, and NONRATT007487.2 in neuropathic pain [13,27] and DISC2, BACE1-AS, and BDNF-AS in depression [28,29,30]. The gene discussed is XIST; the disease is depressive symptom measurement.