Several common genes can be fused with MLL1, including MLL-ENL, MLL-ELL, MLL-AF4, MLL-AF9, MLL-AF10 and MLL-PTD, accounting for 80–90% of MLLs, whereas MLL1-rearranged leukemias account for 10% of all leukemias [31,77]. The gene discussed is ELL; the disease is leukemia.