Additionally, MLL2 has been revealed in genomic studies as a recurrent target for the integration on oncogenic viruses (hepatitis B virus and adeno-associated virus type 2) of hepatocellular carcinoma (HCC) tissues [86,87], indicating a potential relationship of elevated MLL2 expression with liver cancer progression that needs to be further investigated. Here, KMT2B is linked to hepatocellular carcinoma.