SETDB1 functions as a tumor suppressor in Acute Myeloid Leukemia (AML) by promoter histone methylation and repression of tumorigenic genes [115], such as Sineoculis homeobox homolog 1 (Six1), HoxA9 and Dedicator of Cytokinesis 1 (Dock1) [116,117]. The gene discussed is HOXA9; the disease is acute myeloid leukemia.