Lastly, neurodegeneration and memory deficits in Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS) are linked to a global downregulation of the H3K9me3 mark, further demonstrating the implication of SETDB1 in the pathogenesis of neuropsychiatric diseases [129]. The gene discussed is SETDB1; the disease is amyotrophic lateral sclerosis.