One of the first studies was conducted Reynolds et al. in which more than 50 plasma proteins were screened in stroke patients, and it was concluded that the top differentially expressed were S100B, B-type neurotrophic growth factor (BNGF), von Willebrand factor (vWF), monocyte chemotactic protein-1 (MCP-1), and MMP-9 [36]. Here, S100B is linked to stroke disorder.