In this context, new miniaturized biosensing POC prototypes are under development for fast multiplex monitoring of different biochemical and genetic pathways potentially associated with stroke (e.g., MMP9, TNF-α, IL6, S100B, GFAP, microRNA) in minimally invasive blood samples [80,81,82,83,84] (see Table 6). This evidence concerns the gene S100B and stroke disorder.