Six hub proteins, including budding uninhibited by benzimidazoles 1 (BUB1), cyclin B2 (CCNB2), cell division cycle 6 (CDC6), cell division cycle 20 (CDC20), cyclin dependent kinase 1 (CDK1), and minichromosome maintenance complex component 2 (MCM2) were found to be positively correlated with tumor grades of patients from the TCGA–TSCC data set (Supplementary Materials, Figure S1A–F). The gene discussed is BUB1; the disease is neoplasm.