TP53 and breast carcinoma: By analyzing p53 genetic alterations using cBioPortal (http://cbioportal.org, accessed on 11 July 2021) [37,38,39], we observed a high mutation rate in arginine residues of p53 protein in breast carcinoma patients, including R248, R273, R175, R342, R280, R282, R196, R337, R249, and R306 (ranked according to the mutation frequency) (Supplementary Figure S1).