LVOTO and HCM share calcium, TGF-β, POSTN gene encoding periostin (extracellular matrix protein with multiple functions), collagen, PIMREG gene and PIMREG protein (involved in metaphase-to-anaphase transition during mitosis), SNCG gene encoding gamma-synuclein (a member of the synuclein family of proteins, which were believed to be involved in the pathogenesis of neurodegenerative diseases and certain tumors), verapamil (calcium channel blocker), dobutamine (β1-agonist), mavacamten (MYK-461, inhibitor of cardiac myosin ATPase), systolic anterior motion, and death. The gene discussed is PIMREG; the disease is neurodegenerative disease.