In an in vitro model of cisplatin-induced AKI, Tomasoni et al. demonstrated that coincubation of damaged proximal renal tubular epithelial cells with MSC-derived EVs, which are selectively enriched with IGF1R mRNA, enhanced cell proliferation and repair, suggesting that the transfer of this gene to tubular cells is an important mechanism by which MSCs confer renoprotective effects in experimental AKI [92]. This evidence concerns the gene IGF1R and acute kidney injury.