Protein synthesis signaling (p-Akt, p-mTOR, p70S6, and 4EBP-1) and adiponectin-related genes (adiponectin, AdioR1, and APPL1) were found to have significantly increased after aerobic exercise; meanwhile, LC3II was not significantly decreased, suggesting that aerobic exercise might not be sufficient to restore autophagy to the basal level in the early stage of cachexia. The gene discussed is ADIPOQ; the disease is Cachexia.