Autophagy (LC3BII/LC3BI, ATG5, ULK1), the UPS system (FOXO3, MURF1, ATROGIN-1), and protein synthesis (mTOR, 3EBP1, S6rp) were dysregulated during chemotherapy, but exercise leveled off their levels, proving its potential benefit in preventing further disruption by chemotherapy and cancer cachexia [22]. This evidence concerns the gene TRIM63 and cancer.