In skeletal muscle tissue, Ohlendieck, et al. [46] studied the status of dystrophin-associated proteins in the muscle of 17 DMD patients of many age groups; the results exposed a dramatic reduction in all dystrophin-associated proteins in the sarcolemma of the DMD muscle compared with normal muscle and the muscle of a variety of other neuromuscular diseases. The gene discussed is DMD; the disease is neuromuscular disease.