After an initial infectious episode caused by either bacteria or viruses (the first hit), inflammation would be sustained by abnormal metabolic conditions (the second hit), particularly hypercholesterolemia, and eventually be maintained by hypogonadism and/or hyperestrogenism (the third hit), leading to overexpressive Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and reactive prostatic cell. This evidence concerns the gene OLR1 and hyperestrogenism.