NSD3 and osteosarcoma: In addition, the 8p11.2 region is amplified in many cancers [67], leading to the increased expression of NSD3 (Figure 5), and reports have described NSD3 to be essential for tumor maintenance and the suppression of NSD3 expression leads to reduced cell proliferation in lung cancer [77,78,79], breast cancer [80,81], and osteosarcoma [82].