Moreover, MAFs generate an immunosuppressed melanoma TM by multiple mechanisms, such as increasing the expression of various inflammatory and immunosuppressive factors; among others, TGF-ß, IL-6, MMPs, PGE2, COX-2, CXCL5, and PDL1/2, which dramatically impair the anti-tumor activity of immune cells. This evidence concerns the gene IL6 and melanoma.