Viros et al. found that an increased upward scatter and nest formation of intraepidermal melanocytes in the RGP portion of the tumors, thickening of the involved epidermis, sharp demarcation from the surrounding skin, as well as the presence of a larger, rounder, and more pigmented tumor cells were distinguishing features of melanomas with BRAF mutation and tend to occur in the skin without marked solar elastosis in anatomic sites such as the trunk. Here, BRAF is linked to melanoma.