PRKAR1A and acrodysostosis: The heterozygote Prkar1a activating point mutation R368X knock-in mice (Prkar1a[R368X]/[+] mice) had chondrodysplasia and peripheral acrodysostosis affecting the endochondral skeleton, which resulted in shorter tails, shorter length and shorter forelimbs and hindlimbs, compared to their wild type littermates.