A transcriptome profiling of bone cells, derived from a tibial pseudoarthrosis of a NF1 patient, showed that EREG and EGFR1 genes, encoding, respectively, epiregulin and its receptor Epidermal Growth Factor Receptor 1, were among the NF1-deficiency-associated top up-regulated genes [55]. The gene discussed is EREG; the disease is neurofibromatosis type 1.