Interestingly, all the MEN2B MTC patients with skeletal abnormalities had high CHM1 expression, suggesting that the CHM1 aberrant expression in the MEN2B MTC, in early infancy and childhood, could be responsible for alterations at the growth plates of developing bones, leading to the skeletal abnormalities that characterize the MEN2B form of the syndrome. The gene discussed is CNMD; the disease is medullary thyroid gland carcinoma.