GRN and nervous system disorder: It is also known that mutations in splicing important cis-acting elements in AD associated genes, namely presenilin 1 (PSEN1) [52], presenilin 2 (PSEN2) [53], progranulin (GRN) [54], peptidylprolyl cis/trans-isomerase NIMA-interacting 1 (PIN1) [55], and PD related genes, such as MAO-B [16] and PARK2 [18], result in the formation of mRNA isoforms, from which translated proteins influence neurological diseases’ development [18].