Using RNA-seq data of HNC patients, Xing et al. [24] predicted a pseudogene signature, including LILRP1 (leukocyte immunoglobulin-like receptor pseudogene 1), RP6-191P20.5 (retinitis pigmentosa 6 191P20.5 pseudogene), RPL29P19 (ribosomal protein L29 pseudogene 19), TAS2R2P (taste 2 receptor member 2 pseudogene), and ZBTB45P1 (zinc finger and BTB domain-containing 45 pseudogene 1) pseudogenes, related with poor patients’ prognosis, possibly explained by a pseudogene transcript–parental gene interaction, increasing angiogenesis, tumor cell proliferation, and migration [24]. The gene discussed is ZBTB45P1; the disease is neoplasm.