MAPT and Alzheimer disease: Ever since Alois Alzheimer provided the first clinical and pathological description of this disease in 1901, we have learned that Alzheimer’s disease (AD) is a complex and multifactorial condition in which the interplay of both genetic (65%) and lifestyle (35%) factors [1] is involved in the accumulation of protein aggregates of β-amyloid (Aβ) and tau in the brain that ultimately causes neuronal death and loss of gray matter.