APOE and Alzheimer disease: Another gene implicated in lysosome and autophagosome dysfunction and risk for AD is TMEM106B. This gene has been reported to be associated with FTD in granulin (GRN) mutation carriers [85] and with AD interacting with APOE. More recently, Li et al. used a digital deconvolution [86] to estimate the brain cell-type proportion from multiple cohorts.