More recently, cases of MPS with an autosomal dominant form, also classified as distal arthrogryposis type 8 (DA8) [6,7], have been associated with mutations in the embryonic myosin heavy chain gene, MYH3. This is the same gene that is found underlying other forms of distal arthrogryposis (DA1, DA2A or Freeman Sheldon syndrome, and DA2B or Sheldon Hall syndrome). This evidence concerns the gene TPM2 and distal arthrogryposis.