This was suggested for the FMR1 gene, when over 200 CCG repeats cause mental retardation (Fragile-X syndrome), while the premutations of 45–200 repeats are a risk factor for Fragile-X- tremor/ataxia syndrome (FXTAS) in males and premature ovarian failure 1 (FXPOI) in females. Here, FMR1 is linked to fragile X-associated tremor/ataxia syndrome.