FMR1 and premature ovarian failure 1: This was suggested for the FMR1 gene, when over 200 CCG repeats cause mental retardation (Fragile-X syndrome), while the premutations of 45–200 repeats are a risk factor for Fragile-X- tremor/ataxia syndrome (FXTAS) in males and premature ovarian failure 1 (FXPOI) in females.