For example, ATG5-deficient prostate cancer cell line DU145 expresses two different ATG5 alternative transcripts (missing exons 3, or both exons 3 and 6) and exhibits impaired autophagy initiation in response to valproic acid; a defect that could be complemented with the canonical full length ATG5 mRNA [69]. Here, ATG5 is linked to Familial prostate cancer.