SHANK3 and premenstrual tension: Finally, most individuals (approximately 75%) with PMS carry a 22q13.3 deletion greater than 1 Mb [3,9], causing the loss of dozens of genes, in addition to SHANK3. The loss of one copy of these genes is expected to contribute to the clinical presentation of the syndrome, as suggested by genotype-phenotype analyses indicating a positive correlation between the size of the deletion and the number and/or severity of certain clinical traits, such as developmental delay [10,11,12], autistic traits [3], speech/language abilities [4], hypotonia [10,11,12], and dysmorphic features [3,12].