BRD1 and premenstrual tension: Some studies have identified specific genes within the commonly deleted 22q13.3 region as potential contributors to the PMS phenotypes [26,27], suggesting, among the others, a role for the SULT4A1 gene in speech delay and abnormal cerebellar development and function, BRD1 in neuropsychiatric disorders [28], and GRAMD4, SCO2, and TYMP in mitochondrial abnormalities [29].