SHANK3 and premenstrual tension: In some cases, interstitial 22q13.3 deletions, not encompassing SHANK3, have been described in association with a clinical presentation overlapping with some PMS phenotypes [21,22,23]; this suggests the presence of certain genes, proximal to SHANK3, whose haploinsufficiency can cause similar neurobehavioral issues as those observed in the cases with terminal deletions or SHANK3 pathogenic variants.