New genetic techniques have provided new insights into the pathogenesis of UL, with stratification into four main subtypes: mutations of mediator of transcription subunit 12 (MED12), fumarate hydratase (FH), high mobility group AT-hook 2 (HMGA2) translocations and collagen gene deletions [9]. This evidence concerns the gene HMGA2 and uterine corpus leiomyoma.