Of those, the most notable are Dnajc28, Syne2 (synaptic nuclear envelope 2) that are upregulated in the MRL/lpr model compared with both Fn14ko and MRL/+, as well as transthyretin (Ttr) that is downregulated in the lupus-prone mice compared with both controls. The gene discussed is TTR; the disease is systemic lupus erythematosus.