Similarly, Syne2 (spectrin repeat containing nuclear envelope protein 2), a member of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex that tethers the nuclear lamina to the cytoskeleton [63], has been previously identified to be associated with Alzheimer’s Disease (AD) and familial early-onset dementia [38,39]. This evidence concerns the gene SYNE2 and early-onset autosomal dominant Alzheimer disease.