For example, ABCG5/ABCG8 and APOE variants, also called minor FH genes, are generally known to cause sitosterolemia (recessive) or dysbetalipoproteinemia (dominant), respectively, but interestingly, an association with hypercholesterolemia has also been published for some heterozygous variants in both genes, although with a less severe phenotype [47,48,49,50,51]. This evidence concerns the gene APOE and familial hypercholesterolemia.