Regarding APOE, in a French cohort of LDLR/APOB/PCSK9-negative hypercholesterolemia cases with normal triglyceride levels, three out of 229 (1.3%) carried an APOE variant, of which 2 were located in the APOE–LDLR-binding domain [49]. This evidence concerns the gene LDLR and familial hypercholesterolemia.