More variants have been associated with reduced OATP1B1 transporter activity, which, for example, has been shown for the transport of methotrexate in children with acute lymphoblastic leukemia or bilirubin in case of Rotor syndrome, suggesting that more variants in SLCO1B1 can affect statin clearance and are thereby able to evoke SAMS. Here, SLCO1B1 is linked to Rotor syndrome.