In a genome-wide association study in 2008 [44], it was shown that the variant c.521T>C, p.(Val174Ala) in SLCO1B1 (rs4149056) was associated with increased plasma levels of statins and with odds ratios of 4.5 (heterozygous) and 16.9 (homozygous) for developing SAMS in individuals on simvastatin. The gene discussed is SLCO1B1; the disease is short stature-auditory canal atresia-mandibular hypoplasia-skeletal anomalies syndrome.