HDAC9 and Parkinson disease: Protection against α-Syn-mediated toxicity by HDAC inhibition was also shown in human neuroglioma cells and in a drosophila model of Parkinson’s disease where genetic or pharmacological blockade of sirtuin 2, a member of Class-III HDAC family, showed dose-dependent rescue from α-Syn-induced toxicity, supporting a role of α-Syn in histone epigenetic control of gene expression [105].