MRE11 and Nijmegen breakage syndrome-like disorder: Multiple missense variants of MRE11 have been linked to human diseases including progressive myoclonic ataxia (PMA, MRE11A47V) [58], Nijmegen breakage syndrome-like disorder (NBSLD, MRE11D113G) [59], and A-TLD [60,61,62,63,64,65] (Figure 2A).