Interestingly, a pathogenic variant of MRE11 (MRE11G285C) in uterine endometrioid carcinoma displays a similar cellular phenotype with the UFMylation-defective variant of MRE11 (MRE11K282R), implying that MRE11 UFMylation is very likely to be associated with tumorigenesis [31]. Here, MRE11 is linked to endometrial endometrioid adenocarcinoma.