Although heterozygous disease-causing variants in the Special AT-rich sequence-binding protein 2 (SATB2) gene are associated with Glass syndrome (NDD, speech impairment, non-specific dysmorphic features and, frequently, cleft palate or teeth abnormalities, with infrequent epilepsy and no regression), two RTT-like cases have been described, without seizures or regression. This evidence concerns the gene SATB2 and epilepsy.