The HOXA Transcript Antisense RNA Myeloid-specific 1 (HOTAIRM1), a long non-coding RNA critical for kidney differentiation, and the ADAMTS9-AS2 are both downregulated in ccRCC by hypoxia in the form of the spliced cytoplasmic HM1-3 isoform [156] and via miR-27-a3p-mediated modulation of FOXO1, respectively [157]. The gene discussed is HOTAIRM1; the disease is nonpapillary renal cell carcinoma.