Accordingly, the loss of von Hippel-Lindau protein (pVHL) and hypoxia inducible factor (HIF) activation have been implicated in the Warburg effect observed in several tumors and in particular as a hallmark of ccRCC, where aerobic glycolysis is dysfunctional, as well as the accumulation of lipids as a consequence of hypoxia [134,135,136]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.