Targeted exome NGS analysis of patients with idiopathic erythrocytosis by Camps et al. (2016) [14], including known disease-causing oxygen-sensing genes (EPAS1, EGLN1, VHL) and novel candidate genes from oxygen-sensing pathway (EPO, HIF1A, HIF3A, HIF1AN, EGLN2, EGLN3, BHLHE41, OS9, ZNF197, KDM6A) confirmed variants in all known disease-causing genes and identified five novel candidate genes associated with ECYT. The gene discussed is EPAS1; the disease is polycythemia.