Most frequent mutations related to clonal hematopoiesis are reported in three chromatin-related genes: DNMT3A, TET2, and ASXL1. Additional recurrent molecular abnormalities associated to CHIP include mutations in genes encoding for RNA splicing factors, which are also frequently reported in patients affected with MDS and other myeloid neoplasms [21,22,23,24,25,26]. Here, ASXL1 is linked to myelodysplastic syndrome.