LMX1B and open-angle glaucoma: In fact, Park et al. even suggested that the alteration of LMX1B transcription factor function may lead to glaucomatous damage independent of IOP alterations, as they noted that single-nucleotide polymorphisms (SNPs) of LMX1B were also associated with NTG—and highlighting the danger of defining and evaluating POAG singularly through a lens of elevated IOP [36].