LMX1B and open-angle glaucoma: It should be noted that LMX1B mutations have been associated with families affected by nail–patella syndrome (NPS), a rare autosomal dominant developmental disorder with variable presentation, and POAG, suggesting an explanation for the association between NPS and glaucoma (approximately 1/3 of patients with NPS develop glaucoma), though not explaining a mechanism for causation [34,35,36].