NKX2-1 and acute lymphoblastic leukemia: Abnormalities of the RAS/MAPK signaling display a strong enrichment in ETP-ALL and HOXA subgroups, but also occur in TLX1, TLX3, NKX2.1, and NKX2.2 positive T-ALL, although at a lesser extent, while they are absent in the TAL/LMO subgroup [9].