Besides CASP8AP2, two further candidate tumor suppressor genes, i.e., SYNCRIP (encoding hnRNP-Q) and SNHG5 (that hosts snoRNAs), have been recently identified at 6q14.3, ~4Mb apart from CASP8AP2. When codeleted/haploinsufficient, SYNCRIP and SNHG5, alter ribosomal functions, increase leukemia-initiating cell activity, and induce tumor progression [22]. The gene discussed is CASP8AP2; the disease is leukemia.