These rearrangements differ from the other T-ALL translocations involving the 14q32 region, such as the t(5;14)(q35;q32)/BCL11B-TLX3 (see above), due to a more centromeric cluster of 14q32 breakpoints that can be reliably identified with a specifically designed fluorescence in situ hybridization assay. The gene discussed is TLX3; the disease is acute lymphoblastic leukemia.