PHF6 and leukemia: It has been demonstrated that loss of PHF6 is an early mutational event in leukemia transformation and that Phf6 inactivation enhances hematopoietic stem cell (HSC) long-term self-renewal, and hematopoietic recovery after chemotherapy, thus rendering Phf6 knockout HSCs more quiescent and less prone to stress-induced activation [124].