Based on the differentially methylated regions overlapping across the age groups, we highlighted a number of critical developmental genes consistently demonstrating DS-associated changes in the methylation of promoter regions: a morphogen HHIP and regulators of the transcription factors activity: HOXA2, HOXA4, TET1, PRDM8, ZBTB22, and RUNX1. Here, ZBTB22 is linked to Dravet syndrome.