Tracking RUNX1 differential methylation across three ages as a difference between the individuals with and without DS, we observed a remarkable increase in RUNX1 hypermethylation with age; in terms of the delta-beta values, it increased from 0.27 to 0.28 in newborns and toddlers to 0.36 in adults. The gene discussed is RUNX1; the disease is Dravet syndrome.