PRDM8 and hemorrhagic disease: Most of these genes are known to be involved in the manifestation of various clinical phenotypes [38], such as metabolic diseases (CPT1B and BLVRA); hemorrhagic diseases (RUNX1 and GP6); and neuronal disorders (KCNAB3, FAM179B, CCDC60, GRM6, and PRDM8), among others (Table 3).