Compatible with its protein level, NEDD4-2 S342 and NEDD4-2 S448 phosphorylation levels were decreased to 0.61 (t(12) = 13.3, p < 0.001 vs. control animals, Student t-test) and 0.65 times (t(12) = 12.9, p < 0.001 vs. control animals, Student t-test) the control level in the vehicle-treated epilepsy rats, respectively (Figure 3A,C,D and Figure S1). The gene discussed is NEDD4L; the disease is epilepsy.