NEDD4L and epilepsy: Due to upregulation of NEDD4-2 protein level induced by AMPAR antagonists, S342 phosphorylation ratios were reduced to 0.84 and 0.83 times the control level in perampanel and GYKI 52466-treated epilepsy rats, respectively (F(2,17) = 8.3, p = 0.003 vs. vehicle, one-way ANOVA; Figure 3A, E and Figure S1).