Likewise, exosomal ncRNAs BACE1-AS, 51A, 17A, NDM29, BC200, miR-135a, miR-34b, miR-125b and miR-130b [136,200,201,202,219,220,221,222,223,224] and the exosomal proteins GAP43, neurogranin, SNAP25 and synaptotagmin 1 and hemoglobin of neuronal origin have been proposed as early biomarkers of AD and MCI [203,204]. The gene discussed is BACE1; the disease is Alzheimer disease.