AKT1 and ovarian cancer: Several studies revealed that expression of Lewis Y on ovarian cancers could promote cancer cell proliferation by regulating expression and phosphorylation of the molecules in EGFR/PI3K/Akt signaling pathways [21,22] and as a part of integrin αv, β3, and α5β1 to enhance the adhesion and migration of ovarian cancer cells [23,24,25].