Some of them, such as MLK3, TAK1, ASK1, MKK4, MKK7, JNK1, and JNK2, have been demonstrated to regulate cell proliferation, cell survival, cell differentiation, and cell renewal [8,9].We found that receptor tyrosine kinase-like orphan receptor 2 (ROR2) was the most upregulated gene during bladder cancer progression, from NMIBC to MIBC. This evidence concerns the gene MAPK8 and urinary bladder carcinoma.