KEGG pathway enrichment analysis showed that a significant number of differentially expressed proteins in EVs cargo derived from fibroblasts bearing IPF phenotype were mainly related to focal adhesion, PI3K-Akt, and ECM-receptor interaction signaling pathways, which demonstrates that proteins captained in EVs cargo from an IPF phenotype might favor the pathogenesis of IPF. The gene discussed is AKT1; the disease is idiopathic pulmonary fibrosis.