PTEN and Hepatic fibrosis: These genes significantly enriched several remarkable pathways, of which some were down-regulated (Sirtuin signaling pathway, hepatic fibrosis signaling pathway, autophagy, GP6 signaling pathway, ErbB2-ErbB3 signaling, stearate biosynthesis I, fatty acid β-oxidation I, type 2 diabetes mellitus signaling), and the others up-regulated (NRF2-mediated oxidative stress response, PTEN signaling, and superpathway of methionine degradation).