The expression level of H2AFY associated with prognosis in HCC patients [94] and macroH2A1 deletion has been shown to impact the phenotype of HCC cells, eliciting reduced proliferation rate, chemotherapy resistance, and stem-like metabolic rewiring (increased hypoxic responses and glycolysis), leading them to acquire cancer stem cell features, among which the capability to give rise to significantly larger and less differentiated tumors when injected into nude mice [24]. Here, MACROH2A1 is linked to cancer.