Among the most up-regulated genes, HSD17B2 (fold change 263.67) encodes 17β-hydroxysteroid dehydrogenase type 2, an enzyme crucial for steroid hormones metabolism and for intratumoral estrogens and androgens metabolism (intracrinology) impacting tumor progression and patient’s prognosis in sex-steroid-dependent cancers as well as in estrogen and androgen receptor-positive liver cancer [35,36,37,38,39]. The gene discussed is HSD17B2; the disease is liver cancer.