CLOCK and metabolic dysfunction-associated steatohepatitis: Activation/expression of NRF2, a key driver of anti-inflammatory, antioxidant, and cytoprotective responses, transcriptionally impacts the expression of genes managing cellular protection from oxidative stress and inflammation, both biological clock-controlled processes [11] and is involved in the pathogenic mechanisms underlining onset and progression of liver diseases, including NAFLD/NASH and HCC.