GNG12 and neoplasm: The most down-regulated gene, GNG12 (fold change −115.27), encodes guanine nucleotide-binding protein subunit gamma-12, a G protein family member entailed in the modulation of the inflammatory signaling cascade, which when highly expressed in tumor tissue, enhances cancer cell growth and predicts poor prognosis in pancreatic cancer [48] as well as in liver cancer, in this case in cooperation with GNA12 (fold change −1.79) [42].