SPARC and neoplasm: SPARC (secreted protein acidic and rich in cysteine, fold change −36.12) encodes a glycoprotein involved in extracellular matrix remodeling and influencing cell growth and hepatic fibrogenesis in chronic inflammation as well as cell proliferation, migration and invasion, angiogenesis, and tumor progression in HCC, where its decreased expression in tumor tissue predicts poorer prognosis [53,54,55].