PTEN and diabetes mellitus: Performing functional and pathway analyses with IPA exclusively on 1842 circadian genes sorted out from the GSE117459 dataset (see Materials and Methods), we found significant enrichment in seven down-regulated pathways (Sirtuin signaling pathway, hepatic fibrosis signaling pathway, autophagy, GP6 signaling pathway, ErbB2-ErbB3 signaling, stearate biosynthesis I, fatty acid β-oxidation I, type 2 diabetes mellitus signaling), and three up-regulated pathways (NRF2-mediated oxidative stress response, PTEN signaling, superpathway of methionine degradation).