The biological clock plays a critical role in NAFLD onset and progression to NASH and HCC, impacting basic cellular processes, such as autophagy, cell cycle, DNA damage response, xenobiotic detoxification, reactive oxygen species production, and inactivation [10,11]; however, the epigenetic mechanisms involved in HCC and associated with obesity/metabolic syndrome/NAFLD have not been investigated in detail. This evidence concerns the gene CLOCK and metabolic dysfunction-associated steatotic liver disease.