SIRT1 and hepatocellular carcinoma: The high amount of fat in the liver can induce the development of HCC through inflammation, activating specific signal pathways such as those of NF-kB, STAT3/5, JNK, and SIRT1, and consequently the expression of a set of growth factors and cytokines (IL-6, IL-10, TNFα, and lymphotoxins) [3,4].