SIRT1 and myocardial infarction: Researchers found the involvement of sirtuin 1 (SIRT1) and plaque miR-33 on the pro-inflammatory and pro-coagulable state of the coronary thrombus in hyperglycemic patients with ST-elevation acute coronary syndrome, as well as the expression of miR-92a as a vital contributor to the activation of cardiac fibroblasts in post-MI patients [31,32].