Given the recent discovery that elevated ANG 1-7/ANG II ratio predicts a beneficial outcome of HF [66], our present findings are significant in that they suggest that the initial compensatory response in the ACF-induced model of HF in TGR consists of the activation of the vasodilatory/natriuretic axis of the RAS, which may override the effects of activation of the vasoconstrictor/sodium retaining axis. The gene discussed is AGT; the disease is hydrops fetalis.