Along the axis of PC1, ln-XOR correlated strongly with hypoxanthine, xanthine, impaired liver functions (ALT, AST, γGTP, and/or APRI abnormalities, with hepatic steatosis), obesity-related parameters (BMI, VFA, waist circumference, and triglyceride), and various NCS parameters. The gene discussed is GPT; the disease is obesity due to melanocortin 4 receptor deficiency.