GPT and obesity due to melanocortin 4 receptor deficiency: PC1 showed a positive correlation of ln-XOR with impaired liver functions (ALT, AST, γGTP, and/or APRI abnormalities, with hepatic steatosis), xanthine, hypoxanthine, conduction velocity of the peroneal nerve, amplitude potentials (both peroneal and tibial), and obesity-related parameters (BMI, VFA, waist circumference, and triglyceride), as well as negative correlations of ln-XOR with F-waves (both peroneal and tibial), maximum IMT, duration of diabetes, HDL-cholesterol, AAR, GLP1RAs/DPP4is use, retinopathy, ACR, age, and the Brinkman index.