SGCB and memory impairment: Peripheral mechanisms likely also underly the memory enhancing effects in rodents for the likewise poorly brain penetrant sGC stimulator riociguat, which in a novel study by us was found to reverse the short-term memory impairments induced by cerebral vasoconstrictor sumatriptan with an altered dose–response curve, implying that riociguat may act through vasoactive mechanisms [36].